Chemical probes for methyl lysine reader domains.

Chemical probes for methyl lysine reader domains.
Curr Opin Chem Biol. 2016 Jun 24;33:135-141
Authors: James LI, Frye SV
Abstract
The primary intent of a chemical probe is to establish the relationship between a molecular target, usually a protein whose function is modulated by the probe, and the biological consequences of that modulation. In order to fulfill this purpose, a chemical probe must be profiled for selectivity, mechanism of action, and cellular activity, as the cell is the minimal system in which 'biology' can be explored. This review provides a brief overview of progress towards chemical probes for methyl lysine reader domains with a focus on recent progress targeting chromodomains.
PMID: 27348158 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - June 23, 2016 Category: Biochemistry Authors: James LI, Frye SV Tags: Curr Opin Chem Biol Source Type: research