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Pioneering prostate cancer therapy could stop thousands of men needing surgery 

The technology 'fuses' an MRI (magnetic resonance imaging) scanner with ultrasound to identify diseased cells. A precisely targeted laser fibre is then heated up to annihilate them.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Hung-Ming Lam, Eva Corey
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Contributors : Feng Zhou ; Shuai Gao ; Dong Han ; Changmeng CaiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe aberrant activation of the ERG oncogenic pathway due to TMPRSS2-ERG gene fusions is the major driver of prostate cancer initiation and progression. We identified the alpha1 and beta1 subunits of soluble guanylyl cyclase (GUCY1A1, GUCY1B1) as major ERG-regulated genes in prostate cancer cells. Soluble guanylyl cyclase (sGC) is the major mediator of nitric oxide signaling in cells that, upon nitric oxide binding, catalyzes the synthesis of cGMP and subsequently activates PK...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Topline results seem to give support to Blue Earth Diagnostics’ test to help impact treatment decisions for patients. The Burlington, MA-based company presented results from the LOCATE investigational trial at the American Urology Association’s annual meeting. LOCATE is a prospective, multi-center, open label study conducted at 15 sites in the U.S. The study’s primary endpoint measured the percentage of men with suspected biochemical recurrence of prostate cancer following initial prior therapy whose treatment plan was changed following Blue Earth Diagnostics’ 18F fluciclovine PET/CT scan. The ...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news
Source: BMJ Comments - Category: General Medicine Source Type: forums
Administering androgen deprivation therapy (ADT) to men with low-risk prostate cancer improves some short-term outcomes. But is it still active surveillance? And do otherwise healthy men need treatment?Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Condition:   Prostate Cancer Interventions:   Procedure: treatment with focal HIFU;   Biological: PSA dosage;   Device: MRI;   Other: Questionnaires;   Procedure: Prostatic biopsies Sponsor:   Hospices Civils de Lyon Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
By SAURABH JHA Of my time arguing with doctors, 30 % is spent convincing British doctors that their American counterparts aren’t idiots, 30 % convincing American doctors that British doctors aren’t idiots, and 40 % convincing both that I’m not an idiot. A British doctor once earnestly asked whether American physicians carry credit card reading machines inside their white coats. Myths about the NHS can be equally comical. British doctors don’t prostate every morning in deference to the NHS, like the citizens of Oceania sang to Big Brother in Orwell’s dystopia. Nor, in their daily rounds, do the...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: OP-ED Uncategorized AlfieEvans Source Type: blogs
Abstract MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provid...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Clin Lab Med Source Type: research
(Wiley) A new study reveals declines in prostate cancer screening and diagnoses in the United States in recent years, as well as decreases in the use of definitive treatments in men who have been diagnosed.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsA better understanding of these potential pitfalls in the mpMRI-guided Tbx procedure will aid interpretation of a negative Tbx, identify areas for improving technical proficiency, and improve both physician understanding of negative Tbx and patient-management options.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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