Correlation of In Vivo and In Vitro Assay Results for Assessment of Free Radical Scavenging Activity of Green Tea Nutraceuticals

In this study, an orthogonal analysis protocol was designed to evaluate the photostability of a model green tea nutraceutical formulation. Lack of agreement between chemical assay results required correlation to in vivo activity in animal model. Results indicated that photodegraded green tea samples were not only ineffective but also harmful to biological systems. Photodegradation products exerted prooxidant effect rather than the beneficial antioxidant effect. Results of the study confirmed that inappropriate selection of analysis techniques and lack of correlation between in vitro and in vivo assay results might lead to elusive conclusions about the quality of nutraceuticals.
Source: Journal of Food Science - Category: Food Science Authors: Tags: C: Food Chemistry Source Type: research