Safety and tolerability of an anti-CD19 monoclonal antibody, MEDI-551, in subjects with systemic sclerosis: a phase I, randomized, placebo-controlled, escalating single-dose study

Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the...

Source: Arthritis Research and Therapy - June 7, 2016 Category: Rheumatology Authors: Elena Schiopu, Soumya Chatterjee, Vivien Hsu, Armando Flor, Daniel Cimbora, Kaushik Patra, Wenliang Yao, Jing Li, Katie Streicher, Kathleen McKeever, Barbara White, Eliezer Katz, Jorn Drappa, Sarah Sweeny and Ronald Herbst Source Type: research