The effects of androgen deprivation therapy on the 18f-choline uptake in prostate cancer patients undergoing neoadjuvant treatment

Conclusions Few studied have evaluated the impact of ADT on 18F-Choline uptake of the primary PC tumor and its metastasis before RP or RT. With the present study we evaluated how the hormonal therapy can significantly impact on SUVmax of the prostate gland and on the positive location of metastasis. PET/CT could have an important role in the prostate staging before primary treatments, however, before the imaging, a careful evaluation of the hormonal therapy status should be done. Table 1. Differences between groupsVariablesGroup 1 (NO)Group 2 (YES)P valueN patients6217Median age71 (41-87)69 (62-82)0.887Gleason score categories 7 8-1023 (37%) 39 (63%)5 (29%) 12 (81%)0.557PSA levels (before PET)18.15 (2.80-201.00)25.00 (0.00-288.00)0.234PSA categories 20 ng/mL13 (21%) 19 (31%) 24 (48%)4 (24%) 2 (12%) 7 (64%)0.423NCCN category Intermediate High14 (23%) 48 (77%)3 (18%) 14 (82%)0.661PET positivity Prostate Prostate+LN Prostate+LN+bone Prostate+bone Prostate+others40 (65%) 12 (19%) 4 (6%) - 6 (10%)14 (82%) - - 3 (18%) -<0.001SUVmax in prostate7.72 (3.01-29.61)5.34 (2.96-17.91)0.020Treatments RP RP+adjuvant ther RT+ADT ADT Others21 (34%) 1 (2%) 22 (35%) 16 (26%) 2 (3%)4 (24%) 1 (6%) 8 (44%) 4 (24%) 00.652
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA I: Prostate/GU Posters Source Type: research