Synthesis and Biological Evaluation of Novel N' (4-Aryloxybenzylidene)-1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents.

Synthesis and Biological Evaluation of Novel N' (4-Aryloxybenzylidene)-1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents.
Comb Chem High Throughput Screen. 2014 Mar 13;
Authors: Siddiki AA, Bairwa VK, Telvekar VN
Abstract
A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value in the range of 1.5-25 µg/mL.
PMID: 24625232 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - March 13, 2014 Category: Chemistry Authors: Siddiki AA, Bairwa VK, Telvekar VN Tags: Comb Chem High Throughput Screen Source Type: research