miRNAs in lung cancer: A link to aging.

miRNAs in lung cancer: A link to aging. Ageing Res Rev. 2014 Mar 11; Authors: Zagryazhskaya A, Zhivotovsky B Abstract Lung cancer is a leading cause of cancer deaths worldwide. Development of lung cancer is associated with exposure to carcinogens such as tobacco smoke and some environmental factors. The incidence of lung cancer increases with age, particularly after age 60. It was estimated that less than 2% of all lung cancer cases occurred in patients younger than 45; therefore, this type of tumor can be considered as an aging-related disease. MicroRNAs (miRNAs) are small non-coding RNA molecules capable of regulating expression of over 50% of protein-coding genes. miRNAs were shown to play an extremely important role in cell functioning, affecting all biological processes, as well as development of various diseases. Expression profiles of miRNAs are known to be altered in cancer, including lung cancer and also exhibit changes during aging. These RNA molecules are stable in tissue sections and blood and reflect tumor origin, histotype, and stage, which make them candidate diagnostic and prognostic biomarkers. miRNA mimics or inhibitors can be delivered into a cell, with possible therapeutic implications. Here, we review the results obtained during the last year that demonstrate the aging-related regulation of miRNA expression, in association with their role in lung cancer initiation, progression, and resistance to anticancer therapy, as well...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research