Anti Myelin-Associated-Glycoprotein Antibody Peripheral Neuropathy Response to Combination Chemoimmunotherapy With Bendamustine/Rituximab in a Patient With Biclonal IgM κ and IgM λ: Case Report and Review of the Literature

Symptoms of peripheral neuropathy are very common, with conventional estimates of prevalence in the United States in the tens of millions. Approximately 10% of patients with a polyneuropathy of unknown cause have a coexistent monoclonal gammopathy. Many of these are incidental gammopathies, unrelated to the neuropathy. However, there are numerous entities in which the gammopathy induces the neuropathy, and is therefore the prime target for therapy (eg, amyloidosis, Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS), immunoglobulin [Ig]M deposition disease, etc).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research