Abstract A13: {beta}2-adrenergic receptor as a potential differentiation marker in prostate cancer

Conclusion: Low protein level of ADRB2 in prostate cancer tissue is correlated with high Gleason grade, and is also associated with biochemical recurrence after radical surgery. Knockdown of ADRB2 in the cell line LNCaP induced reduction in the expression of differentiation markers. Our observations suggest ADRB2 as a marker of differentiation in prostate cancer cells, and indicate that ADRB2 down-regulation might be one of the drivers of this process.Citation Format: Håkon Ramberg, Helene H. Grytli, Peder R. Braadland, Wanzhong Wang, Heidi K. Nielsen, Kurt A. Krobert, Finn Olav Levy, Anders Bjartell, Aud Svindland, Kristin Austlid Taskén. β2-adrenergic receptor as a potential differentiation marker in prostate cancer. [abstract]. In: Proceedings of the AACR Special Conference: Developmental Biology and Cancer; Nov 30-Dec 3, 2015; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(4_Suppl):Abstract nr A13.

Source: Molecular Cancer Research - May 2, 2016 Category: Cancer & Oncology Authors: Ramberg, H., Grytli, H. H., Braadland, P. R., Wang, W., Nielsen, H. K., Krobert, K. A., Levy, F. O., Bjartell, A., Svindland, A., Tasken, K. A. Tags: EMT and Plasticity: Poster Presentations - Proffered Abstracts Source Type: research