International Society for Heart and Lung Transplantation (ISHLT) 2016 Scientific SessionsInternational Society for Heart and Lung Transplantation (ISHLT) 2016 Scientific Sessions

Read clinically focused news coverage of key developments from ISHLT 2016. Medscape Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Conference Coverage Source Type: news

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We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction mac...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
With the development of medical technology, transplantation has prevailed and become an important tool in the treatment of disease. According to the WHO ’s statistics, as of 2015, approximately 120000 cases of solid organ transplantation have been performed globally. Renal transplantation is the most common, followed by liver transplantation, heart transplantation, lung transplantation, hematopoietic stem cell transplantation, etc. [1]. And, in re cipients of transplantation, seizures usually occur during the postoperative period [2,3].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Tags: Review Source Type: research
This thirty-fifth adult lung and heart –lung transplant report summarizes data from 64,803 adult lung and 4,054 adult heart-lung transplants performed through June 30, 2017 and reported to the International Thoracic Organ Transplant Registry. With each year's report we now also provide more detailed analyses on a particular focus theme . Since 2013, these have been donor and recipient age; retransplantation; early graft failure; indication for transplant; and allograft ischemic time; and in 2018, multiorgan transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Models of power delivery within an intact organism have been limited to ionizing radiation and to some extent sound&magnetic waves for diagnostic purposes. Traditional electrical power delivery within intact human body relies on implanted batteries that limit the amount and duration of delivered power. The efficiency of current battery technology limits substantial demand to be met; such as continuous operation of an implantable artificial heart pump within a human body.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Pre-Clinical Science Source Type: research
This study aimed to evaluate the impact of agonal time and warm ischemic time on early survival in Category III donation after circulatory death (DCD) donor lung transplants (LTx) using data reported to the International Society for Heart and Lung Transplantation (ISHLT) DCD LTx Registry.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
The majority of children supported with ventricular assist devices (VAD) are bridged to heart transplantation. Although bridge to recovery has been reported, low recovery patient numbers has precluded systematic analysis. The aim of this study was to delineate recovery rates, predictors of recovery, and to report the long-term follow-up after VAD explantation in children.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
The past year has been notable for multiple celebrations and symposia around the globe commemorating the first heart transplant performed worldwide by Dr. Christiaan Barnard at Groote Schuur Hospital in Cape Town, South Africa, on December 3, 1967, and the first heart transplant performed in the United States by Dr. Norman Shumway at Stanford Hospital on January 6, 1968. Since then, the field of heart transplantation has grown dramatically, with steady increases in the number of heart transplants performed worldwide annually, accompanied by improvement in post-transplant survival and other favorable outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
In a recently published article, Asleh et al. demonstrated that cardiac allograft recipients with a baseline serum urate higher than 7 mg/dL are at a two-fold higher risk for developing cardiac allograft vasculopathy (CAV) and that the increase in serum urate during follow-up is associated with plaque progression independently of renal function, sirolimus therapy, and other comorbidities. Εven though there are data about the role of urate in endothelial dysfunction and inflammation, the authors conclude that although serum urate may be a reliable biomarker for CAV progression, its implication in the pathogenesis of...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
This is an exciting time for pediatric thoracic organ transplantation. At the end of last year, we celebrated the 50th anniversary of the first orthotopic heart transplantation. Since then, the field of pediatric heart transplantation has grown dramatically and heart transplantation in children is now performed routinely at many centers throughout the world. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation is the largest source of worldwide heart transplant data with over 14,000 transplants in children reported.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
The first registry of patients with pulmonary arterial hypertension (PAH), established by the US National Heart, Lung, and Blood Institute (NHLBI) in 1981, reported a median survival of 2.8 years in the empirical therapy era.1 Shortly after bosentan was approved in the early 2000s, the French registry reported a one-year survival of 88% in patients with PAH,2 while the Chinese registry reported 1,3, and 5-year survivals of 68%, 38.9%, and 20.8% respectively, in patients with idiopathic and familial PAH who were treated with conventional therapies.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Invited Commentary Source Type: research
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