Impact of slow K + currents on spike generation can be described by an adaptive threshold model

In this study, we investigated the impact of slow K+ currents on spike generation mechanism by reducing a detailed conductance-based neuron model. We showed that the detailed model can be reduced to a multi-timescale adaptive threshold model, and derived the formulae that describe the relationship between slow K+ current parameters and reduced model parameters. Our analysis of the reduced model suggests that slow K+ currents have a differential effect on the noise tolerance in neural coding.
Source: Journal of Computational Neuroscience - Category: Neuroscience Source Type: research