Hope for transplant patients: Baboons survive more than two years with pig hearts

Researchers at the National Heart, Lung and Blood Institute in Maryland say the technique, called immunomodulation, is ready to be used in human trials for the first time (stock image pictured).
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Naranjo M, Lo KB, Mezue K, Rangaswami J Abstract Pulmonary hypertension is not uncommon in patients with renal disease and vice versa; therefore, influences treatments and outcomes. There is a large body of literature on pulmonary hypertension in patients with kidney disease, its prognostic implications, economic burden, and management strategies. However, the converse, namely the hemodynamic effects of pulmonary hypertension on kidney function (acute and chronic kidney injury) is less studied and described. There is also increasing interest in the effects of pulmonary hypertension on kidney transplant out...
Source: Current Cardiology Reviews - Category: Cardiology Tags: Curr Cardiol Rev Source Type: research
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Contributors : Stephen Dalton ; Thomas Colunga ; Miranda Hayworth ; Luoman Chen ; Kristopher L NazorSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiens ; Mus musculusMesothelium is a multipotent resident progenitor cell of the coelomic organs that functions in organogenesis, repair and possible regeneration. We used hESCs to generate mesothelium of the epithelial and mesenchymal forms. Mesenchymal derivatives of mesothelium have been previously reported to function in tissue repair by promoting and participating in angiog...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Mus musculus Source Type: research
Publication date: Available online 5 October 2018Source: Heart &LungAuthor(s): Koji Ueyama, So Miyahara, Yujiro Ide, Kazuhisa Sakamoto, Hideo Kanemitsu, Kazuhiro Yamazaki, Tadashi Ikeda, Akihiro Aoyama, Hiroshi Date, Kenji Minatoya 
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
This study assessed the prevalence of syncope in pediatric PAH and examined its clinical, hemodynamic, and prognostic importance. This retrospective study assessed clinical data, including syncope status, from 78 children (37 girls) with idiopathic and heritable PAH (median age at diagnosis, 11  years). Patients were classified as syncopal or non-syncopal, and clinical data from the two groups were compared. The primary outcome was a composite of lung transplantation and cardiac mortality. Overall, 31 (38%) children had a history of syncope at presentation. Median age at diagnosis, sex ra tio, brain natriuretic peptid...
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction (CLAD). Our study aimed to evaluate prevalence and prognostic importance of obstructive and restrictive CLAD phenotypes with or without identifiable underlying cause to validate the recently proposed classification system for CLAD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
V-Wave said today it launched a new trial of its minimally invasive interartrial shunt designed to treat patients with symptomatic heart failure. The new Relieve-HF trial aims to enroll 500 patients in a pivotal study of the device, which is designed for patients with NHYA Class III and ambulatory Class IV symptomatic heart failure, the Israel-based company said. “The interatrial shunt provides a novel therapeutic approach for patients with chronic HF. The shunt is implanted through a catheter inserted in a vein in the leg. Prior clinical experience demonstrated device and implantation procedure safety, and stat...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cardiovascular Clinical Trials V-Wave Source Type: news
Aortic valve incompetence in left ventricular assist device (LVAD) patients is a significant management problem, leading to increased workload on the LVAD and inadequate systemic perfusion. During continuous LVAD therapy even mild aortic incompetence is problematic, associated with reduced aortic leaflet opening, progressive fusion of the leaflets and worsening valvular incompetence. Therefore, repair or replacement of the valve is required at the time of LVAD implant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Case Anecdotes, Comments and Opinions Source Type: research
In this study, 22 patients were transplanted with preexisting DSA, and 43 patients developed ndDSA posttransplant. Pretransplant (P
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Source Type: research
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