Starting too soon: upstream reading frames repress downstream translation

Upstream open reading frames (uORFs) are known to regulate a few specific transcripts, and recent computational and experimental studies have suggested candidate uORF regulation across the genome. In this issue, Johnstone et al (2016) use ribosome profiling to identify translated uORFs and measure their effects on downstream translation. Furthermore, they show that regulatory uORFs are conserved across species and subject to selective constraint. Recognizing the potential of uORFs in regulating translation expands our understanding of the dynamic regulation of gene expression.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Protein Biosynthesis & Quality Control, RNA Biology, Systems & Computational Biology News [amp ] Views Source Type: research