Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice

This study was conducted in mice. Whether or not the results are applicable to human remains further elucidation. In addition, we were unable to confirm if the strain of mice (C57BL/6XSv129) at the age of 41–68 weeks old has the ‘cohesin-loss’ phenotype. WIDER IMPLICATIONS OF THE FINDINGS Investigating Mater's functional mechanisms could provide fresh insights into understanding how the ageing-related oocyte quality decline occurs. LARGE SCALE DATA N/A. STUDY FUNDING AND COMPETING INTEREST(S) This work was supported by the research grant from Chinese NSFC to P.Z. (31071274). We have no conflict of interests to declare.

http://molehr.oxfordjournals.org/cgi/content/short/22/4/252?rss=1

Source: Molecular Human Reproduction - March 31, 2016 Category: Molecular Biology Authors: Lu, Y.-q., He, X.-c., Zheng, P. Tags: Articles Source Type: research