Paraoxonase-1 overexpression prevents experimental abdominal aortic aneurysm progression

In conclusion, decreased circulating PON1 activity is associated to human and experimental AAA. PON1 overexpression in mice protects against AAA progression by reducing oxidative stress, apoptosis and inflammation, suggesting that strategies aimed at increasing PON1 activity could prevent AAA.

Source: Clinical Science - March 18, 2016 Category: Biomedical Science Authors: BURILLO, E., TARIN, C., TORRES-FONSECA, M. M., FERNANDEZ-GARCIA, C. E., MARTINEZ-PINNA, R., MARTINEZ-LOPEZ, D., LLAMAS-GRANDA, P., CAMAFEITA, E., LOPEZ, J. A., VEGA DE CENIGA, M., AVIRAM, M., EGIDO, J., BLANCO-COLIO, L. M., MARTIN-VENTURA, J. L. Tags: PublishAheadOfPrint Source Type: research