Supressive and Prophylactic Potentials of Flavonoid-rich Extract of Adansonia digitata L. Stem Bark in Plasmodium berghei-infected Mice

This study investigated the suppressive and prophylactic potentials of flavonoid-rich extracts of Adansonia digitata stem bark in Plasmodium berghei infected mice. The albino mice were administered with two different doses (200 and 400 mg kg–1 b.wt.) of extract for five consecutive days. About 5 mg kg–1 b.wt. day–1 dose of artemether-lumefantrine and 5 mg kg–1 b.wt. day–1 dose of chloroquine were used as reference drugs while the control mice received only the vehicle (5% v/v tween 80). In the prophylactic groups, the mice were pretreated daily for five days before they were challenged with inoculums of 1×107 chloroquine-sensitive P. berghei infected erythrocyte intraperitoneally. The results showed a dose dependent chemosupression in the extract treated groups. The 400 mg kg–1 b.wt., was more effective with respect to the parasite clearance than the 200 mg kg–1 b.wt., dose. The chemosupression caused by Artemether-Lumefantrine (AL) and chloroquine (CQ) treated groups were significantly (p
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research