Abstract B35: Concurrent use of alisertib and vaccinia virus demonstrate increased in vitro efficacy against breast cancer models with elevated numbers of cancer stem-like cells

Conclusions: Combination therapy of alisertib and OVV has a significantly higher anti-cancer cell activity in vitro than either agent used alone, and it is particularly applicable for treatment of cells with CSC phenotype. In vivo studies are currently in progress. The combined treatment of alisertib and OVV represents novel therapeutic approach in treating breast cancer with increased numbers of CSCs, resistance to standard therapies and worse clinical outcomes. The results present a novel treatment approach with high translational potential.Citation Format: Malgorzata Gil, Marcin Komorowski, Danuta Kozbor, Mateusz Opyrchal. Concurrent use of alisertib and vaccinia virus demonstrate increased in vitro efficacy against breast cancer models with elevated numbers of cancer stem-like cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research; Oct 17-20, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(2_Suppl):Abstract nr B35.
Source: Molecular Cancer Research - Category: Cancer & Oncology Authors: Tags: Targeted Therapies: Poster Presentations - Proffered Abstracts Source Type: research