Comorbid tics have no effect on response to cognitive-behavioural therapy in youth with obsessive-compulsive disorder

Tic-related obsessive-compulsive disorder (OCD) is a DSM-5 diagnostic subtype that is estimated to occur in 10–40% of cases with childhood onset.1 Studies comparing tic-related and non-tic-related OCD have found consistent differences in sex, onset age, comorbidity and course, but inconsistent differences in OCD symptoms and prevalence of OCD and tics in first-degree relatives.1 ,2 Medication trials have indicated that tic-related OCD is less responsive to sertraline, fluvoxamine and paroxetine; however, tic history appears to have no effect on the response of OCD in youth to either individual or group cognitive-behavioral therapy (CBT).1 ,3 Study aims were to use a broad definition of tic-related OCD to examine whether children with tics in the Pediatric OCD Treatment …
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Tourette syndrome (TS) and Chronic motor/vocal Tic Disorder (CTD) are neurodevelopmental conditions defined by the occurrence of multiple tics. Besides the well-known association with attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
This report presents a  case of TS reemergence against the background of immunological reaction or PANDAS with a late adolescent onset.
Source: Wiener Medizinische Wochenschrift - Category: General Medicine Source Type: research
AbstractTourette syndrome is a heterogeneous neurobehavioral disorder manifested by childhood-onset motor and phonic tics, often accompanied by a variety of behavioral comorbidities, including attention deficit and obsessive compulsive disorder. Treatment must be tailored to the needs and goals of the individual patients and their families. All patients should receive education on the condition and, if possible, engage behavioral therapy targeted towards tics and/or comorbidities. Pharmacological therapies, such as alpha agonists, topiramate, and vesicular monoamine transport type 2 inhibitors, are generally used as first-...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Tic disorders (TD) are a group neuropsychiatric disorders with childhood onset characterized by tics, i.e. repetitive, sudden, and involuntary movements or vocalizations; and Tourette syndrome (TS) is the most severe form of TD. Their clinical manifestations are diverse; and are often associated with various psychopathological and/or behavioral comorbidities, including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and sleep disorders. Individual severity and response to treatment are highly variable, and there are some refractory cases, which are less responsive ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Although several lines of evidence support the hypothesis of a dysregulation of serotoninergic neurotransmission in the pathophysiology of obsessive-compulsive disorder (OCD), there is also evidence for an involvement of other pathways such as the GABAergic, glutamatergic, and dopaminergic systems. Only recently, data obtained from a small number of animal studies alternatively suggested an involvement of the endocannabinoid system in the pathophysiology of OCD reporting beneficial effects in OCD-like behavior after use of substances that stimulate the endocannabinoid system. In humans, until today, only two case reports a...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract Neuropsychiatric disorders often manifest with abnormal control of motor behavior. Common symptoms include restricted and repetitive patterns of behavior (RRBs). Cortico-basal ganglia circuits have been implicated in the etiology of RBBs. However, there is a vast range of behaviors encompassed in RRBs, from simple explosive motor tics to rather complex ritualized compulsions. In this review, we highlight how recent findings about the function of specific basal ganglia circuits can begin to shed light into defined motor symptoms associated with neuropsychiatric disorders. We discuss recent studies using ge...
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Tags: Curr Opin Genet Dev Source Type: research
In this study, we enlisted 475 children (290 males and 185 females; ratio 1.6:1), aged 4 to 14 years, who were affected by primary headache. In direct interviews, children and parents gave information on the association of their headache with, attention-deficit/hyperactivity disorder, learning disabilities, tics, anxiety, depression, and obsessive-compulsive disorder. Other 475 children with no history of headache or recognized neurological conditions were matched for age, sex, race, and socioeconomic status and were used as controls. RESULTS: A significant association of primary headache was found with anxiety and depression (p-value
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study provides new insights into behavioral therapy for tics by identifying two distinct aspects of tic-associated sensations that include premonitory urges.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
CONCLUSIONS: These findings provide strong evidence for striatal CINs as a critical cellular target that may contribute to pathophysiology in children with rapid-onset OCD symptoms, and perhaps in other conditions. PMID: 32539528 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
Tourette syndrome (TS), also known as Tourette ’s disorder, is a neurodevelopmental disorder with onset in early childhood characterized by multiple motor tics and at least one vocal tic that have been present for longer than 1 year. TS is a model neuropsychiatric disorder, in that the vast majority of affected individuals, whether ascertained in clinical or community settings, experience at least one co-occurring psychiatric disorder, such as attention-deficit/hyperactivity disorder, obsessive-compulsive disorder, and/or mood, anxiety, and specific learning disorders (1).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
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