SIRT1 Influences the Sensitivity of A549 Non-small Cell Lung Cancer Cell Line to 
Cisplatin via Modulating the Noxa Expression

Conclusion Higher SIRT1 expression may induce resistance to cisplant in A549 cells. SIRT1 inhibition may improve the sensitivity of A549/DDP cells to cisplantin though modulating the Noxa expression. DOI: 10.3779/j.issn.1009-3419.2016.02.01
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research