The role of the uncertainty of measurement of serum creatinine concentrations in the diagnosis of acute kidney injury.

The role of the uncertainty of measurement of serum creatinine concentrations in the diagnosis of acute kidney injury. Ren Fail. 2016 Mar;38(2):305-10 Authors: Kin Tekce B, Tekce H, Aktas G, Uyeturk U Abstract Uncertainty of measurement is the numeric expression of the errors associated with all measurements taken in clinical laboratories. Serum creatinine concentration is the most common diagnostic marker for acute kidney injury. The goal of this study was to determine the effect of the uncertainty of measurement of serum creatinine concentrations on the diagnosis of acute kidney injury. We calculated the uncertainty of measurement of serum creatinine according to the Nordtest Guide. Retrospectively, we identified 289 patients who were evaluated for acute kidney injury. Of the total patient pool, 233 were diagnosed with acute kidney injury using the AKIN classification scheme and then were compared using statistical analysis. We determined nine probabilities of the uncertainty of measurement of serum creatinine concentrations. There was a statistically significant difference in the number of patients diagnosed with acute kidney injury when uncertainty of measurement was taken into consideration (first probability compared to the fifth p = 0.023 and first probability compared to the ninth p = 0.012). We found that the uncertainty of measurement for serum creatinine concentrations was an important factor for correctly diagnosi...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research