The effect of chenodeoxycholic acid and the bile acid sequestrant colesevelam on glucagon‐like peptide‐1 secretion

ConclusionsCDCA increased GLP‐1 and glucagon secretion, and delayed gastric emptying. We speculate that bile acid‐induced activation of TGR5 on L cells increases GLP‐1 secretion, which in turn may result in amplification of glucose‐stimulated insulin secretion. Furthermore our data suggest that colesevelam does not have an acute effect on GLP‐1 secretion in humans.

Source: Diabetes, Obesity and Metabolism - February 17, 2016 Category: Endocrinology Authors: Morten Hansen, Matthijs J. Scheltema, David P. Sonne, Jakob S. Hansen, Michael Sperling, Jens F. Rehfeld, Jens J. Holst, Tina Vilsbøll, Filip K. Knop Tags: ORIGINAL ARTICLE Source Type: research