Early- vs late-onset subcortical vascular cognitive impairment

Conclusions:
EO-SVCI patients showed more vascular related factors, while LO-SVCI patients exhibited more Alzheimer disease–related characteristics. The greater number of lacunes in EO-SVCI might account for the more severe frontal network disruption and frontal-executive dysfunction, while the greater amyloid burden in LO-SVCI might account for the more severe cortical and hippocampal atrophy. Our findings suggest that the age at onset is a crucial factor that determines distinct features in SVCI patients, such as pathologic burden, structural changes, and cognitive function.

Source: Neurology - February 8, 2016 Category: Neurology Authors: Jang, Y. K., Kwon, H., Kim, Y. J., Jung, N. Y., Lee, J. S., Lee, J., Chin, J., Im, K., Jeon, S., Lee, J. M., Seong, J.-K., Kim, J. H., Kim, S., Choe, Y. S., Lee, K.-H., Kim, S. T., Kim, J. S., Lee, J. H., Na, D. L., Seo, S. W., Kim, H. J. Tags: Vascular dementia, Assessment of cognitive disorders/dementia ARTICLE Source Type: research