High-resolution oesophageal manometry and 24-hour impedance-pH study in systemic sclerosis patients: association with clinical features, symptoms and severity.

CONCLUSIONS: The presence and severity of gastroesophageal symptoms may not accurately reflect the seriousness of oesophageal involvement. GORD severity is associated with presence of restrictive lung pattern and pulmonary fibrosis. Oesophageal manometry and 24-hour pH study should be considered more frequently in the assessment of SSc patients. PMID: 26843456 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Related Links:

Authors: Qiu Y, Hu JL, Zhao CC, Zhang JQ, Wu F, Ma BL, Feng Y, Ruan KF Abstract Background: Gastroesophageal reflux disease (GERDs) is a common chronic digestive system disease, in which the symptoms of reflux esophagitis (RE) seriously affect the quality of life. Aims: We aimed to study the therapeutic effect of Zhujie Hewei granules (ZHG) on reflux esophagitis in model rats. Materials and Methods: A rat model of RE was established with the steps of half pylorus ligation, cardiotomy, and hydrochloric acid perfusion. The rats in treatment groups were orally administered with 1.30, 2.60, or 5.20 g/kg ...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
AbstractOptimal wound care is an essential component in the management of systemic sclerosis (SSc) digital ulcers (DUs). DU debridement has been suggested to reduce ulcer-related pain and improve tissue healing. However, only a minority of rheumatologists perform DU debridement, and there is no standard of care/protocol. Our objectives were to (i) evaluate the current evidence for the use of debridement in DU management and (ii) assess whether there are any specific protocols. A systematic literature review was performed searching the PubMed database (between 01/01/1950 –01/03/2019) in accordance with PRISMA guidelin...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Most people know about the damaging effects that binge drinking can bring to someone’s life. Loss of enjoyment of life, losing family relationships, financial and career struggles, homelessness, and legal consequences are just the tip of the iceberg. However, it can be more difficult to realize the long-term effect of binge drinking on the body, because you cannot always see it. Frequent binge drinking poses many dangerous health risks, and many of them can lead to death. Facts on Long-Term Effect of Binge Drinking on the Body For men, binge drinking is defined as consuming five or more drinks within about two hour...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol dependence alcohol treatment alcohol treatment center binge binge drinking Source Type: blogs
(Ohio State University) Acid reflux drugs that are sometimes recommended to ease stomach problems during cancer treatment may have an unintended side effect: impairment of breast cancer survivors' memory and concentration.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
AbstractPurpose of reviewHigh resolution esophageal manometry (HRM) has expanded understanding of esophageal motor function. The Chicago Classification scheme has allowed systematic categorization of the myriad of manometric parameters identified during HRM. Multichannel intraluminal impedance pH has enhanced ambulatory reflux monitoring through complete assessment of esophageal content transit. However, the clinical implications of identified minor esophageal functional disorders remain unclear.Recent findingsEsophagogastric junction outlet obstruction is defined by esophagogastric junction obstruction with preserved peri...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
To the Editor, Morphea is an autoimmune disease that causes fibrosis of the skin that may result in significant morbidity. Eosinophilic fasciitis (EF) may be considered a deeper form of morphea, and features of both morphea and EF can be present in individual patients. Morphea and EF have been postulated to have pathogenic features that overlap with systemic sclerosis (Laxer and Zulian, 2006). In these diseases, dysregulated immune responses are thought to induce fibrosis (Torok et al., 2019). Treatment of these diseases with non-specific immunosuppressants such as corticosteroids is often ineffective and associated with toxicity.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letters to the Editor Source Type: research
Systemic sclerosis (SSc) is a rare and severe connective tissue disease combining auto-immune and vasculopathy features, ultimately leading to organ fibrosis. Impaired angiogenesis is an often silent and life-threatening complication of the disease. We hypothesize that CCN3 (NOV), a member of the CCN family of extra-cellular matrix proteins, which is an antagonist of the pro-fibrotic protein CCN2 (CTGF) as well as a pro-angiogenic factor, is implicated in SSc pathophysiology.We performed skin biopsies on 26 SSc patients, both in fibrotic and non-fibrotic areas for 17 patients, and collected 18 healthy control skin specimen...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
New England Journal of Medicine,Volume 382, Issue 3, Page 296-298, January 2020.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research
January 16 2020 Edition.-----The US assassination of a very senior Iranian general and the aftermath have been all consuming internationally. We have seen a missile response and Trump seems to have stood down for now. What this week will bring is hard to guess – but calm may break out for a few months, but it seems unlikely to last. Good to see the Phase 1 Trade Deal between the USA and China has finally been signed. It won't make a huge actual difference but Trump needed a win optically!In Australia it has been all about the bushfires and its consequen ces. As of Sunday it does seem that ScoMo is gradually shifting ...
Source: Australian Health Information Technology - Category: Information Technology Authors: Source Type: blogs
This study confirms the efficacy of autologous stem cell transplantation in real-life practice for severe systemic sclerosis using non myeloablative conditioning. Careful cardio-pulmonary assessment to identify organ involvement at patient referral, reduced cyclophosphamide doses and CD34+ selection may improve outcomes. The study was registered at ClinicalTrials.gov: NCT02516124. PMID: 31949011 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
More News: Acid Reflux | Dysmotility | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Heartburn | Rheumatology | Scleroderma | Study