Effect of Type II Diabetes on Rat Bladder Contractility.

Effect of Type II Diabetes on Rat Bladder Contractility. Am J Physiol Renal Physiol. 2016 Jan 28;:ajprenal.00511.2015 Authors: Kendig DM, Ets HK, Moreland RS Abstract Type II diabetes is the most prevalent form of diabetes. One of the primary complications of diabetes that significantly affects quality of life is bladder dysfunction. Many studies on diabetic bladder dysfunction have been performed in models of Type I diabetes; however, few have been performed in animal models of Type II diabetes. Using the Zucker Diabetic Fatty (ZDF) rat model of Type II diabetes we examined the contractility and sensitivity of bladder smooth muscle in response to mediators of depolarization-induced contraction, muscarinic-receptor mediated contraction, ATP-induced contraction, and neurogenic contraction. Studies were performed at 16 and 27 weeks of age to monitor the progression of diabetic bladder dysfunction. Voiding behavior was also quantified. The entire bladder walls of diabetic rats were hypertrophied as compared to that of control rats. Contractility and sensitivity to carbachol and ATP were increased at 27 weeks in bladder smooth muscle strips from diabetic rats, suggesting a compensated state of diabetic bladder dysfunction. Purinergic signaling was increased in response to exogenous ATP in bladders from diabetic animals; however, the purinergic component of neurogenic contractions was decreased. The purinergic component of neurogenic cont...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research