Dietary fat and corticosterone levels are contributing factors to meal anticipation.

Dietary fat and corticosterone levels are contributing factors to meal anticipation. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 27;:ajpregu.00308.2015 Authors: Namvar S, Gyte A, Denn M, Leighton B, Piggins HD Abstract Daily restricted access to food leads to the development of food anticipatory activity and metabolism, which depends upon an as yet unidentified food-entrainable oscillator(s). A pre-meal anticipatory peak in circulating hormones including corticosterone is elicited by daily restricted feeding. High fat feeding is associated with elevated levels of corticosterone with disrupted circadian rhythms and a failure to develop robust meal anticipation. It is not clear whether the disrupted corticosterone rhythm resulting from high fat feeding contributes to attenuated meal anticipation in high fat fed rats. Our aim was to better characterise meal anticipation in rats fed low or high fat diet, and to better understand the role of corticosterone in this process. To this end we utilised behavioural observations, hypothalamic c-Fos expression and indirect calorimetry to assess meal entrainment. We also used the glucocorticoid receptor antagonist, RU486, to evaluate the role of corticosterone in meal anticipation in rats given daily access to a meal with different fat content. Restricted access to a low fat diet led to robust meal anticipation as well as entrainment of hypothalamic c-Fos expression, metabolism and circulating...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research