Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia [Basic Sciences]

Conclusions—
The cytokine IL-4 improves long-term neurological outcomes after stroke, perhaps through M2 phenotype induction in microglia/macrophages. These results are the first to suggest that immunomodulation with IL-4 is a promising approach to promote long-term functional recovery after stroke.

Source: Stroke - January 25, 2016 Category: Neurology Authors: Liu, X., Liu, J., Zhao, S., Zhang, H., Cai, W., Cai, M., Ji, X., Leak, R. K., Gao, Y., Chen, J., Hu, X. Tags: Animal Models of Human Disease, Treatment, Ischemic Stroke Basic Sciences Source Type: research