Effects of extradural cortical stimulation on motor recovery in a rat model of subacute stroke.

CONCLUSIONS: ECS in the subacute phase improved the behavior motor function in the stroke rat model, and induced a significant axonal sprouting in the peri-infarct area. PMID: 25735240 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

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ConclusionCollectively our data suggest that the bioactive chemical pool which is responsible for the therapeutic effects of EW can be extracted in petroleum ether, and fractionated to a relatively small multiple components. Such components include known anti-inflammatory chemicals, which may contribute to the possible microglia polarization in brain lesion during the recovery of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe present method did not only preliminarily reveal the active substances and mechanism of NAC in treatment of IS from the perspective of network pharmacology, but show its potential application for research and development of other TCM prescriptions.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionsThe incidence of PSE after mechanical thrombectomy was low in our cohort. All blood biomarkers displayed interesting sensitivity and specificity. However, the number of PSE cases was small and more studies are needed on risk factors for PSE after mechanical thrombectomy. The potential of blood markers of brain injury markers to contribute to assessment of PSE risk should be explored further.This article is part of the Special Issue "Seizures &Stroke".
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Source: Neurological Sciences - Category: Neurology Source Type: research
AbstractBackgroundThe Aphasia Rapid Test (ART) is a screening questionnaire used for examining language in acute stroke patients. The ART was initially developed and validated in French. The purpose of this study was to assess the inter-rater reliability of Italian ART.MethodsThe original version of the ART was translated into Italian. The inter-rater reliability was assessed by two independent neurologists who were blind to each other ’s ratings in 52 acute post-stroke patients.ResultsThe 52 patients (28 men, 24 women; mean age 73.73  ± 28.99 years) were included within 1 week of strok...
Source: Neurological Sciences - Category: Neurology Source Type: research
AbstractPosterior circulation strokes affect the vertebrobasilar arterial system, account for about 20 –25% of all ischemic strokes, and are a significant cause of patient disability and mortality. Diagnosis can be challenging; clinical presentation and common pitfalls facing posterior circulation stroke have been discussed elsewhere. In the first part of the review, we focus on the imaging, discus sing the information that can be gathered through a correct selection and interpretation of different possible studies helping to achieve an early diagnosis and to select the best medical treatment. In the second part of t...
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: June 2019Source: Revista Portuguesa de Cardiologia (English Edition), Volume 38, Issue 6Author(s): Gonçalo J. Morgado, Inês R. Cruz, Ana Catarina Gomes, Ana Rita Almeida, Maria José Loureiro, Carlos Cotrim, Hélder PereiraAbstractA 24-year-old woman who was 11 weeks pregnant and had a mechanical mitral valve presented at the emergency department with ischemic stroke. Although treatment with aspirin and unfractionated heparin was initially successful, subsequent management was almost impossible, as she eventually suffered a right hemispheric stroke, requiring percutaneous interven...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
This study aims to analyze the incidence and short-term outcomes associated with stroke (ischemic and hemorrhagic) after implantation of LVAD.MethodsStudy cohorts were identified from the National Inpatient Sample database from January 2009 to September 2015 using ICD 9 codes. The primary outcome was an incidence of stroke and secondary outcomes were associated mortality, length of stay and cost of hospitalization. Multivariate logistic regression analysis was performed to analyze adjusted in-hospital mortality.ResultsUse of LVAD increased significantly from 2009 to 2014 (2,278 in 2009 to 3,730 in 2014 (Ptrend
Source: Indian Heart Journal - Category: Cardiology Source Type: research
AbstractThe poor clinical relevance of experimental models of stroke contributes to the translational failure between preclinical and clinical studies testing anti-inflammatory molecules for ischemic stroke. Here, we (i) describe the time course of inflammatory responses triggered by a thromboembolic model of ischemic stroke and (ii) we examine the efficacy of two clinically tested anti-inflammatory drugs: Minocycline or anti-CD49d antibodies (tested in stroke patients as Natalizumab) administered early (1  h) or late (48 h) after stroke onset. Radiological (lesion volume) and neurological (grip test) outcomes we...
Source: Translational Stroke Research - Category: Neurology Source Type: research
Traumatic cerebral aneurysms are histologically dissecting aneurysms or pseudoaneurysms, thus requiring parent artery occlusion for cure. Combination of endovascular parent artery occlusion and extracranial-intracranial bypass is considered optimal to obtain complete obliteration of the aneurysm and to avoid hemodynamic hypoperfusion. However, endovascular parent artery occlusion of the supraclinoid internal carotid artery (ICA) is at risk of ischemic complications due to distal coil protrusion to adjacent perforating arteries or distal embolism of the thrombi generated in the coil mass.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Case Report Source Type: research
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