3D Printing for Liver Tissue Engineering: Current Approaches and Future Challenges

Abstract Recent developments in 3D printing have greatly accelerated progress in the field of liver tissue engineering by enabling the fabrication of more tissue-mimetic structures capable of restoring function. A variety of 3D printing and additive manufacturing techniques ranging from stereolithography to direct ink writing have shown great promise in liver tissue engineering and the study of cellular interactions. Despite these advances, however, there is significant room for improvement. Furthermore, because of the enormous capabilities of 3D printing, methods to analyze complex heterogeneous tissues in vitro have yet to be perfected. Investigations into the ability of 3D printing to recreate the macro- and microstructural components of the liver are still in their infancy. These specific issues need to be addressed in combination with massive scale up if 3D-printed tissue-engineered livers are to reach clinical relevance.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 17 August 2019Source: Cirugía Española (English Edition)Author(s): Luis M. Marín-Gómez, Gonzalo Suárez-Artacho, Javier Padillo-Ruiz, Miguel A. Gómez-Bravo
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 16 August 2019Source: IDCasesAuthor(s): Nicholas Cheronis, Dustin Carr, Nitin BhanotAbstractNocardiosis is a potentially life-threatening infection that affects both immunocompetent and immunosuppressed hosts. We discuss a case of an elderly gentleman with history of orthotopic liver transplantation who presented with cellulitis of his left forearm. When he did not respond to the typical antibiotic coverage for bacterial cellulitis, skin biopsy was performed. N. arthritidis was identified as the pathogen, a relatively newly identified human pathogen first described to cause human disease in 2004.
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 August 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Manon Allaire, Hélène GilgenkrantzSummaryThe aging of the population, the increased prevalence of chronic liver diseases in elderly and the need to broaden the list of potential liver donors enjoin us to better understand what is an aged liver. In this review, we provide a brief introduction to cellular senescence, revisit the main morphological and functional modifications of the liver induced by aging, particularly concerning metabolism, immune response and regeneration, and try to elud...
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Hepatocellular carcinoma (HCC) is one of the quickest growing causes of cancer death in the northern hemisphere. Transplant and resection, the only treatments considered curative, are feasible in only a small minority of patients. Consequently, the landscape of HCC treatment has greatly expanded over the past 10 years. Patients are undergoing treatment with a wide variety of nonoperative interventions, including transarterial chemoembolization and radioembolization using Yttrium-90, and an expanding array of systemic treatments, including sorafenib, regorafenib, and nivolumab.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
BC Transplant says a misunderstanding about the guidelines concerning alcohol abstinence and liver transplants triggered a human rights complaint filed earlier this week by a B.C. man who has end-stage liver disease.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/British Columbia Source Type: news
Chronic inflammation in end-stage renal disease (ESRD) is partly attributed to gut bacterial translocation (GBT) due to loss of intestinal epithelium integrity. Increased levels of circulating lipopolysaccharide (LPS) –a surrogate marker of GBT– contribute to maintain a chronic inflammatory state. However, circulating LPS can be neutralized by lipoproteins and transported to the liver for elimination. While ESRD-associated GBT has been widely described, less is known about its changes and impact on clinical outcome after kidney transplantation (KT). One hundred and forty-six renal transplant recipients with ser...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS Non-invasive investigations of the liver microcirculation and hemoglobin oxygenation were shown to be predictive factors for EAD following liver transplantation. PMID: 31417074 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Objective: The aim of this study was to compare outcomes between living donor liver transplant (LDLT) and deceased donor liver transplant (DDLT) at a single center to demonstrate the advantages of LDLT and provide justification for the increased utilization and application of this procedure. Summary of Background Data: LDLT comprises a very small percentage of all liver transplants performed in the United States, this despite its advantages and a shortage of the availability of deceased donor organs. Methods: A retrospective review of all adult LDLT (n = 245) and DDLT (n = 592) performed at a single center over 10 ...
Source: Annals of Surgery - Category: Surgery Tags: PAPERS OF THE 139TH ASA ANNUAL MEETING Source Type: research
Conclusions: To our knowledge, this is the first RCT demonstrating the impact of THMP after LT. The magnitude of effect on LT outcomes, hospital readmissions, and QOL suggests that the adoption of telemedicine has great potential for other major operations.
Source: Annals of Surgery - Category: Surgery Tags: PAPERS OF THE 139TH ASA ANNUAL MEETING Source Type: research
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