Abstract A90: Dichloroacetate can overcome drug resistance via decreased ABC drug transporter expression and PDK2 inhibition

Conclusion: DCA may be an effective chemo-sensitizing agent in a wide range of MDR cancers, acting by reducing drug transporter expression and inhibiting PDKs.Citation Format: Santhi Achuthan, Richard Callaghan, Anneke C. Blackburn. Dichloroacetate can overcome drug resistance via decreased ABC drug transporter expression and PDK2 inhibition. [abstract]. In: Proceedings of the AACR Special Conference: Metabolism and Cancer; Jun 7-10, 2015; Bellevue, WA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(1_Suppl):Abstract nr A90.

http://mcr.aacrjournals.org/cgi/content/short/14/1_Supplement/A90?rss=1

Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Achuthan, S., Callaghan, R., Blackburn, A. C. Tags: Therapeutic Targets From Cancer: Poster Presentations - Proffered Abstracts Source Type: research