NETosis promotes cancer-associated arterial microthrombosis presenting as ischemic stroke with troponin elevation

Large elevations of high sensitive Troponin T (hsTnT) in ischemic stroke patients is associated with a poor outcome. In a pilot study we found a high prevalence of malignancies among these patients. Since neutrophil extracellular traps (NETs) have been linked to cancer-associated thrombosis, we hypothesized that the concomitant cerebral and myocardial ischemia could be the result of a NET-induced hypercoagulable state.

http://www.thrombosisresearch.com/article/S0049-3848(16)30009-3/abstract?rss=yes

Source: Thrombosis Research - January 12, 2016 Category: Hematology Authors: Charlotte Thålin, Melanie Demers, Bo Blomgren, Siu Ling Wong, Magnus von Arbin, Anders von Heijne, Ann Charlotte Laska, Håkan Wallén, Denisa D. Wagner, Sara Aspberg Tags: Full Length Article Source Type: research