In vitro biofilm production of Candida bloodstream isolates: any association with clinical characteristics?

In vitro biofilm production of Candida bloodstream isolates: any association with clinical characteristics?
J Med Microbiol. 2015 Dec 17;
Authors: Pongrácz J, Benedek K, Juhász E, Iván M, Kristóf K
Abstract
Candida spp. are a leading cause of bloodstream infection (BSI) associated with high mortality rates. Biofilm production is a virulence factor of Candida spp., and has been linked with poor clinical outcome. The aim of our study was to assess biofilm production of Candida bloodstream isolates at our institute, and to determine if in vitro biofilm production was associated with any clinical characteristics of infection. During the four-year study period, 93 cases of Candida BSI were analyzed. The most frequently isolated species was C. albicans (66.7 %), followed by C. glabrata (9.7 %), C. parapsilosis (9.7 %), C. tropicalis (9.7 %), and C. krusei (4.3 %). Biofilm production was more prevalent among non-albicans Candida spp. (77.4 %) than C. albicans (30.6 %) (p = 0.02). Abdominal surgery was identified as a risk factor of BSI caused by biofilm producing non-albicans Candida isolates. No risk factors predisposing to bloodstream infection caused by a biofilm producing C. albicans isolate were identified. Biofilm production was not verified as a risk factor of mortality.
PMID: 26678484 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - December 17, 2015 Category: Microbiology Authors: Pongrácz J, Benedek K, Juhász E, Iván M, Kristóf K Tags: J Med Microbiol Source Type: research