Systematic Comparisons of Formulations of Linear Oligolysine Peptides with siRNA and Plasmid DNA

This article is protected by copyright. All rights reserved. Linear oligolysine peptides with 16 or more lysines can effectively encapsulate plasmid DNA (pDNA) into monodisperse nanoparticles for gene transfer into the cells. However, the linear oligolysine peptides are not capable of forming monodisperse complexes with siRNA, hence they are ineffective in siRNA delivery into cells. Since the linear peptides have a limited rotation freedom, they are more suitable for cellular delivery of pDNA which has a higher rotation freedom than the more physically rigid siRNA.
Source: Chemical Biology and Drug Design - Category: Biology Authors: Tags: Research Article Source Type: research