Mastectomy Pricy Option for Early Breast CancerMastectomy Pricy Option for Early Breast Cancer
Higher complication rates with mastectomy and reconstruction make this early breast cancer therapy option more costly than lumpectomy and radiation, but the value of care is secondary to clinical considerations. Medscape Medical News
ConclusionsCollectively, our results provide evidence for a novel mechanism by which ERβ exerts oncosuppressive effect in AR-positive TBNC through direct and indirect interactions with AR. Moreover, ERβ expression may identify a new subset of TNBC that would respond more favorable to anti-androgens.
ConclusionUTMD can improve Endostar delivery in the targeting tumor tissue and mediate synergistic antiangiogenetic and antitumor effects, which may be a potential therapeutic strategy for refractory breast cancer.
AbstractPurposeThe prevalence and clinical relevance ofTP53 andPIK3CA mutations in pretreatment breast cancer have been previously reported. However, little is known regarding these mutations in residual tumor tissues after neoadjuvant chemotherapy. Here, we investigated the association betweenTP53 andPIK3CA mutations in residual disease and survival of breast cancers.MethodsTP53 andPIK3CA somatic mutations were examined in 353 post-neoadjuvant chemotherapy residual tumor tissues by Sanger sequencing. Survival curves of patients withTP53 andPIK3CA mutations were compared using the Kaplan –Meier method.ResultsFifty-si...
Publication date: Available online 23 April 2019Source: Materials Science and Engineering: CAuthor(s): Mariadhas Valan Arasu, A. Madankumar, J. Theerthagiri, Sunitha Salla, S. Prabu, Hyun-Seok Kim, Naif Abdullah Al-Dhabi, Selvaraj Arokiyaraj, Veeramuthu DuraipandiyanAbstractZnO nanoparticles with flakes-like structures were synthesized by simple wet chemical route using triethanolamine as a mild base. The well distributed ZnO nanoflakes onto carbon nanoplates (ZnO/C) were prepared by wet impregnation method. The crystalline structure and purity of the synthesized samples was inspected using XRD. The shape, structural morph...
Conclusions: Formononetin enhances the tumoricidal effect of everolimus by inhibiting the activity of Akt. PMID: 31007702 [PubMed]
In conclusion, this protein can be used for animal immunization toward preparation of a new monoclonal antibody that can be introduced as a drug in the treatment of breast cancer. PMID: 31009334 [PubMed - in process]
This study provides insight into the experiences of young women living with advanced breast cancer. Because these women may not appear ill to the general population, their needs and struggles are not well understood. The results of this study can be a baseline for additional research and clinical interventions. PMID: 31007263 [PubMed - in process]
Triple-negative breast cancer (TNBC) tumors with estrogen receptor-beta and a mutated p53 tumor suppressor might be responsive to tamoxifen, a series of preclinical studies suggests.Reuters Health Information
(Georgetown University Medical Center) A new study suggests that Oncotype DX-guided treatment could reduce the cost for the first year of breast cancer care in the US by about $50 million (about 2 percent of the overall costs in the first year). The study by Georgetown Lombardi Comprehensive Cancer Center and National Cancer Institute researchers was published April 24, in JNCI.
Date: Wednesday, 05 15, 2019; Speaker: Lucile Adams-Campbell, Ph.D., Professor of Oncology, Georgetown University; 10; Masur Auditorium ; CME Credit; Videocast Event