Mastectomy Pricy Option for Early Breast CancerMastectomy Pricy Option for Early Breast Cancer
Higher complication rates with mastectomy and reconstruction make this early breast cancer therapy option more costly than lumpectomy and radiation, but the value of care is secondary to clinical considerations. Medscape Medical News
Multiple randomized studies have demonstrated that breast-conserving therapy (partial mastectomy plus whole breast radiation) can yield survival outcomes equivalent to those of mastectomy (1). However, newer population-based data suggest that breast cancer –specific survival and overall survival with breast-conserving therapy may actually be better than those with mastectomy (2-8). How is this possible? How can removal of the breast yield outcomes inferior to those of a therapy that leaves most of the breast intact and where in-breast failures are r eported to occur in approximately 5% to 10% of patients at 10 y...
Authors: Li B, Zhu J, Meng L Abstract Actin‑like protein 8 (ACTL8) is a member of the cancer‑testis antigens (CTA) family, which is mainly localized in the cytoplasm and generally expressed in the testis. The association between ACTL8 and various types of cancer, including glioblastoma and breast cancer, has previously been demonstrated. However, whether ACTL8 is involved in the development of head and neck squamous cell carcinoma (HNSCC) remains unknown. In the present study, the expression of ACTL8 in patients with HNSCC was analyzed in The Cancer Genome Atlas (TCGA) dataset, clinical tissues and cell li...
Sphingomyelin synthase 1 regulates the epithelial‑to‑mesenchymal transition mediated by the TGF‑β/Smad pathway in MDA‑MB‑231 cells. Mol Med Rep. 2018 Dec 04;: Authors: Liu S, Hou H, Zhang P, Wu Y, He X, Li H, Yan N Abstract Breast cancer is the most common cancer in women and a leading cause of cancer‑associated mortalities in the world. Epithelial‑to‑mesenchymal transition (EMT) serves an important role in the process of metastasis and invasive ability in cancer cells, and transforming growth factor β1 (TGF‑β1) have been investigated for promoting EMT. However, in...
Xiao-Xiao Wu, Grace Gar-Lee Yue, Jin-Run Dong, Christopher Wai-Kei Lam, Chun-Kwok Wong, Ming-Hua Qiu, Clara Bik-San Lau
Pelagia G. Tsoutsou, Khalil Zaman, Silvia Martin Luesma, Laurene Cagnon, Lana Kandalaft, Marie-Catherine Vozenin
In patients with HER2-positive breast cancer treated with anthracyclines plus trastuzumab, can adding lisinopril or carvedilol reduce the risk of cardiotoxicity?
A comparison of chemotherapy regimens plus anti-HER2 therapy in the neoadjuvant setting tested whether the addition of anthracyclines is necessary for patients with HER2-positive breast cancer.
Having a baby temporarily increases the risk of breast cancer by about 80% compared to the risk in women who have never given birth, researchers behind a new study have concluded.Reuters Health Information