Sub-Nanogram Detection of RDX Explosive by Monoclonal Antibodies.

Sub-Nanogram Detection of RDX Explosive by Monoclonal Antibodies. Monoclon Antib Immunodiagn Immunother. 2015 Aug;34(4):225-7 Authors: Ulaeto DO, Hutchinson AP, Nicklin S Abstract Polyclonal and monoclonal antibodies were raised to protein carrier molecules haptenized with RDX, a major component of many plastic explosives including Semtex. Sera from immunized mice detected RDX protein conjugates in standard ELISA. Clonally purified monoclonal antibodies had detection limits in the sub-ng/mL range for underivatized RDX in competition ELISA. The monoclonal antibodies are not dependent on the presence of taggants added during the manufacturing process, and are likely to have utility in the detection of any explosive containing RDX, or RDX contamination of environmental sites. PMID: 26252765 [PubMed - in process]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research

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