Is acute stress and plasminogen activator inhibitor polymorphism associated with acute ischemic stroke?

Identifying the cause of ischemic stroke (IS) in young adults is of major importance in preventing stroke recurrence. In most cases, IS is a multifactorial disease with genetic predisposition, whereas the inherited risk is likely to be multigenic. Alterations in thrombosis and fibrinolysis comprise important parts of stroke pathophysiology. Plasminogen activator inhibitor type-1 (PAI-1) is an important component of the coagulation system that is a strong inhibitor of fibrinolysis in the circulation.
Source: Clinical Neurology and Neurosurgery - Category: Neurosurgery Authors: Source Type: research