Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer.

Relationship between SDF-1G801A polymorphism and its expression in Tunisian patients with colorectal cancer. J Immunoassay Immunochem. 2015;36(2):182-94 Authors: Amara S, Chaar I, Khiari M, Ounissi D, Hmida AB, Mzabi SR, Bouraoui S Abstract The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic variant was higher in CRC patients with TNM stage II and III, the SDF-1 expression was significantly increased from normal mucosa to primary tumor (p < 0.05). CRC patients have higher frequency of A allele (52.01%) than controls (26.8%) (P = 0.0001). Thus, SDF-1 polymorphism is a risk factor of colorectal cancer susceptibility in our population, the polymorph genotype of SDF-1 maybe associated with clinical manifestations in CRC patients in Tunisia. PMID: 24825098 [PubMed - indexed for MEDLINE]
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research