β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

Conclusion:
These findings provide insight into conditions that control tumor cell invasion by identifying signaling through β
2
-adrenoceptors as a regulator of invadopodia formation. These findings suggest novel pharmacological strategies for intervention, by using β-blockers to target β
2
-adrenoceptors to limit tumor cell dissemination and metastasis.

Source: Breast Cancer Research - November 25, 2015 Category: Cancer & Oncology Authors: Sarah CreedCaroline LeMona HassanCindy PonSabine AlboldKeefe ChanMatthew BerginskiZhendong HuangJames BearJ. LaneMichelle HallsDavide FerrariCameron NowellErica Sloan Source Type: research