Differences in abuse potential of ADHD drugs measured by contrasting poison centre and therapeutic use data - Jensen LS, Pagsberg AK, Dalhoff KP.

Context. Atomoxetine (ATX) is the treatment of choice for attention deficit hyperactivity disorders with co-morbid risk of drug abuse, although its abuse potential needs to be qualified. The purpose of this study is to analyse ATX misuse in relation to the...
Source: SafetyLit: All (Unduplicated) - Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

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In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal samples from disparate regions of the world, recruited either for clinical, genetic epidemiological or pharmacogenomic studies of ADHD, we assembled recursive-partitioning frameworks (classification tree analyses) with clinical, demographic, and ADGRL3 genetic information to predict SUD susceptibility. Our results indicate that SUD can be efficiently and robustly predicted in ADHD participants. The genetic models used remained highly eff...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: SNP genotyping by SNP array Homo sapiens Source Type: research
Contributors : Michele Vacca ; Antonio Vidal-Puig ; Brian Y Lam ; Marcella MaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusTGF β/BMP family member Bone Morphogenetic Protein 8b (Bmp8b) is upregulated in NASH (Western Diet -WD- Model), acute liver damage (CCl4 model) and by Partial Hepatectomy (PH). Absence of Bmp8b reduces liver inflammation and fibrosis in the NASH model (WD). In the acute (3days) CCl4 model, absence of B mp8b impacts acute inflammatory responses, hepatic stellate cells (HSC) activation, and compensatory hepatocyte proliferation; defective inflammatory pathway...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Publication date: Available online 30 March 2020Source: Journal of Organometallic ChemistryAuthor(s): Olga N. Gorunova, Ivan M. Novitskiy, Yuri K. Grishin, Igor P. Gloriozov, V.A. Roznyatovsky, Victor N. Khrustalev, Konstantin A. Kochetkov, Valery V. Dunina
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research
We sought to better characterize differences in transplant outcomes between patients with alcoholic cardiomyopathy and those with other forms of cardiomyopathy in a national cohort.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (548) Source Type: research
Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality following lung transplantation, affecting up to 30% of recipients within 72 hours of transplantation1. Published perioperative risk factors include a history of donor smoking2,3 or heavy donor alcohol use4, longer graft ischemic times2, volume of intraoperative fluid administered5, and higher recipient BMI2,3,6. Our aim was to identify additional intraoperative risk factors for PGD after lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (811) Source Type: research
The objective of this study was to analyze those risk factors of CINV through a systematic literature review.MethodsWe searched MEDLINE to identify articles that addressed patient-related risk factors of CINV through clinical studies.ResultsA total of 49 articles were selected for this study. A total of 28 patient-related risk-factors that significantly impact the risk of CINV were documented. Three factors are demographically related, 17 factors are intrinsic in nature and innate to patient's physiology or influenced by physiology, and eight factors are extrinsic in nature. At least five studies identified seven risk fact...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Testino G, Pellicano R PMID: 32221278 [PubMed - as supplied by publisher]
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
We’re tackling a few urgent questions from parents in this time of coronavirus and COVID-19. Are you wondering if babies and children should continue to have vaccines on schedule? Thinking about how to manage regular medical appointments, and which situations require in-person visits to a pediatric practice? Read on. Should parents take babies for initial vaccines right now? What about toddlers and older children who are due for vaccines? The answer to this question is going to depend on many factors, including what your doctor’s office is offering. As with all health care decisions, it comes down to weighing r...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Adolescent health Children's Health Health care Parenting Vaccines Source Type: blogs
ABSTRACTSerum lipid abnormalities (dyslipidemias) are major risk factors for cardiovascular disease in type 2 diabetes. The features of diabetic dyslipidemia are elevated plasma concentrations of triglyceride (TG) ‐rich lipoproteins (TRLs), small dense low‐density lipoprotein cholesterol (sdLDL‐C) and decreased plasma high‐density lipoprotein cholesterol (HDL‐C) concentration
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: JDI UPDATES Source Type: research
Condition:   Inflammatory Bowel Disease Patients Intervention:   Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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