Eighteen cases of liver injury following ingestion of Polygonum multiflorum - Dong H, Slain D, Cheng J, Ma W, Liang W.
OBJECTIVES: Polygonum multiflorum is a popular Chinese herbal medication. In this case series, we report on 18 otherwise healthy non-viral hepatitis patients who developed liver dysfunction following consumption of P. multiflorum alone. METHODS: Concurrent...
Trends of mortality associated with extrahepatic complications of chronic liver disease might be changing. We studied trends in mortality from extrahepatic complications of viral hepatitis, alcoholic liver disease (ALD), and nonalcoholic fatty liver disease in the United States (US).
Liver dysfunction induced by Levothyroxine Sodium Tablets (Euthyrox®) in a hypothyroid patient with Hashimoto's thyroiditis: case report and literature review. Endocr J. 2019 Jun 18;: Authors: Yu H, Zhang W, Shen C, Zhang H, Zhang H, Zhang Y, Zou D, Gong X Abstract A 49-year-old woman with hypothyroidism developed liver dysfunction after increasing dose of levothyroxine (L-T4) (Euthyrox®) from 25 μg to 50 μg. Viral hepatitis, autoimmune hepatitis and non-alcoholic steatohepatitis (NASH) were ruled out with examinations. She had no concurrent medication and had no history of infectious, ch...
Authors: Zhang H, Bai Y, Gao M, Zhang J, Dong G, Yan F, Ma Q, Fu X, Zhang Q, Li C, Shi H, Ning Z, Dai J, Li Z, Ming J, Xue Q, Si C, Xiong H Abstract Immune-mediated liver injury plays a crucial role in the pathogenesis of liver diseases, which can result from viral infections, autoimmunity, alcohol intake, and drug use. Concanavalin A (Con A)-induced hepatitis is a well-characterized murine model with similar pathophysiology to that of human viral and autoimmune hepatitis. Capsaicin, a selective agonist of the transient potential vanilloid subfamily member 1 (TRPV1) receptor, exhibits anti-inflammatory effects on v...
Conclusion: SBP due to multidrug resistant bacteria is a growing problem, and one should consider reported resistance profiles for the decision-making process of empirical first-line treatment prescription. PMID: 31214551 [PubMed - in process]
Authors: Roman S Abstract Occult hepatitis B infection (OBI) is the presence of hepatitis B virus (HBV) DNA in the liver and/or serum (
Authors: Larrey D, Meunier L, Ursic-Bedoya J Abstract Liver biopsy is still useful in selected clinical situations in which it is the only tool to obtain information necessary for the diagnosis, the prognosis, and the decision for treatment. Main examples are viral hepatitis with confounding co-morbidities, non alcoholic fatty liver disease, and autoimmune liver diseases. PMID: 31208539 [PubMed]
CONCLUSION: At each stage of patient engagement, opportunities for improvement were identified. Understanding the local cascade of care and factors associated with achieving cascade milestones will help prioritize initiatives to facilitate access to DAA therapy in Alberta. PMID: 31222618 [PubMed - as supplied by publisher]
We read with great interest the recent study by Borst et al. characterizing the rapid loss of Kupffer cells (KCs) and their subsequent replacement by monocyte-derived macrophages in the setting of acute viral hepatitis.1 This phenomenon of KC depletion has previously been reported following other inflammatory stimuli such as acetaminophen intoxication, bacterial infection and non-alcoholic steatohepatitis (NASH).2 –4 In response to these findings, and to an Editorial in the Journal of Hepatology5 questioning whether this pattern is observable in all liver diseases, Kessler et al.
Conclusions: Among NBNC-HCC patients, heavy alcohol use or any other identifiable cause was not found in 38.0%. These NBNC-NA-NO HCC patients showed a high prevalence of HBcIgG positivity and metabolic risk factors, suggesting that prior hepatitis B virus infection and metabolic risk factors may be major contributing factors in the hepatocarcinogenesis in NBNC-NA-NO patients. PMID: 31189301 [PubMed - as supplied by publisher]
Conclusion: Our data indicate that the risk of microvascular invasion is highest in tumors localized to segment 8. The size and number of HCC tumors were not associated with an increased risk of microvascular invasion. PMID: 31186641 [PubMed]