Predictive value of glycated hemoglobin (HbA1c) and body mass index (BMI) for pre-treatment neuropathy in patients of multiple myeloma

Conclusion Use of TNSr which incorporates electrophysiological abnormalities in addition to clinical manifestations, improves detection rate of neuropathy. We found that high HbA1c and high BMI together are risk factors for neuropathy at diagnosis in MM patients. Teaser We assessed 29 newly diagnosed patients of multiple myeloma for peripheral neuropathy using Total Neuropathy Score- reduced (TNSr) and clinical (TNSc) versions. 51.7% and 17.2% patients had neuropathy by TNSr and TNSc respectively. HbA1c ≥5.6% and BMI ≥23.7 kg/m2 predicted baseline neuropathy. This may indicate the contribution of abnormal glucose metabolism and metabolic syndrome to pre-treatment neuropathy in patients with multiple myeloma.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research