TNF‐α stimulates System A amino acid transport in primary human trophoblast cells mediated by p38 MAPK signaling

In conclusion, TNF‐α regulates System A activity through increased SNAT1 and SNAT2 transporter protein expression in PHTs. These findings suggest that p38 MAPK may represent a critical mechanistic link between elevated proinflammatory cytokines and increased placental amino acid transport in obese and GDM pregnancies associated with fetal overgrowth. Altered placental amino acid transport is a common pathway which leads to pathological fetal growth. This study demonstrates that TNF‐α regulates amino acid transport activity in primary placental trophoblast cells via p38 MAPK‐dependent mechanism.
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research