Suppression of TGF{beta} and Angiogenesis by Type VII Collagen in Cutaneous SCC

Conclusions:
Type VII collagen suppresses TGFβ signaling and angiogenesis in cutaneous SCC. Patients with RDEB SCC may benefit from anti-angiogenic therapy.

Source: JNCI - October 16, 2015 Category: Cancer & Oncology Authors: Martins, V. L., Caley, M. P., Moore, K., Szentpetery, Z., Marsh, S. T., Murrell, D. F., Kim, M. H., Avari, M., McGrath, J. A., Cerio, R., Kivisaari, A., Kahari, V. M., Hodivala-Dilke, K., Brennan, C. H., Chen, M., Marshall, J. F., O'Toole, E. A. Tags: Article Source Type: research