Resolution of Chlamydia trachomatis infection is associated with a distinct T cell response profile.

In this report, we present immune profiling data of subjects enrolled in a multi-center study of Ct genital infection. CD4(+) and CD8(+) T cells from subjects grouped into disease-specific cohorts were screened using a Ct proteomic library to identify the antigen specificities of recall T cell responses after natural exposure by measuring IFN-γ levels. We identified specific T cell responses associated with resolution of infection, including unique antigens identified in subjects who spontaneously cleared infection and different antigens associated with Ct-related sequelae such as TFI. These data suggest that novel and unique Ct T cell antigens identified in individuals with effective immune responses can be developed as targets for vaccine development, and by excluding antigens associated with deleterious sequelae, immune-mediated pathologies may be circumvented.
PMID: 26446421 [PubMed - as supplied by publisher]

Source: Clinical and Vaccine Immunology - October 7, 2015 Category: Allergy & Immunology Authors: Picard MD, Bodmer JL, Gierahn TM, Lee A, Price J, Cohane K, Clemens V, DeVault VL, Gurok G, Kohberger R, Higgins DE, Siber GR, Flechtner JB, Geisler WM Tags: Clin Vaccine Immunol Source Type: research