Opioid associated intravenous and cutaneous microvascular drug abuse (skin-popping) masquerading as Degos disease (malignant atrophic papulosis) with multiorgan involvement.

CONCLUSION: Our patient's biopsy along with the rapid response to eculizumab indicates that this distinct thrombotic microangiopathy is another complement mediated thrombotic microangiopathy syndrome. Opioid thrombotic microangiopathy has a varied clinical presentation and can mimic other catastrophic microangiopathy syndromes, all of which have in common a responsiveness to complement inhibition. PMID: 26437280 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/26437280?dopt=Abstract

Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Magro CM, Toledo-Garcia A, Pala O, Momtahen S, Shapiro L Tags: Dermatol Online J Source Type: research