Clinical and Microbiological Outcomes in Patients with Streptococcus Anginosus Group Bacteremia Identified Through Use of a Rapid Microarray Assay.

Clinical and Microbiological Outcomes in Patients with Streptococcus Anginosus Group Bacteremia Identified Through Use of a Rapid Microarray Assay. J Med Microbiol. 2015 Sep 25; Authors: Wenzler E, Chandrasekaran V, Salvador P, Anwar M, Pancholi P, McGwire BS Abstract Limited data exist evaluating outcomes in patients with serious S. anginosus group infections, particularly bacteremia. A retrospective, single-center cohort study was conducted to characterize potential risk factors along with clinical and microbiological outcomes in patients with S. anginosus group bacteremia (SAGB). Adult inpatients with SAGB identified by Verigene Gram-Positive blood culture assay between 3/2013-4/2014 were included. Patients ≤ 18 or >89 years, those with SAGB identified at an outside facility, or incarcerated were excluded. The 34 patients who met inclusion criteria were 57±14 years old, had a median Charlson index of 4 [1-6], and 10 (29%) were immunosuppressed at baseline. Almost half (47%) received antibiotics in the previous 90 days. Twelve (35%) patients had gastrointestinal malignancies and the commonest source of bacteremia was the gastrointestinal tract (53%). The primary species responsible for SAGB was S. anginosus (68%), and overall susceptibility to penicillin was 91%. Patients were most often treated with a β-lactam/β-lactamase inhibitor combination (36%) for a duration of 8 [4-13] days. Length-of-stay (LOS) and infection-relate...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research