Medical News Today: Brain defects behind tinnitus and chronic pain identified

The abnormalities in the brain that result in people having tinnitus and chronic pain have been identified, opening the door to a potential cure for the conditions.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news

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Publication date: Available online 1 September 2018Source: NeuroscienceAuthor(s): P. Balaram, T.A. Hackett, D.B. PolleyAbstractDebilitating perceptual disorders including tinnitus, hyperacusis, phantom limb pain and visual release hallucinations may reflect aberrant patterns of neural activity in central sensory pathways following a loss of peripheral sensory input. Here, we explore short- and long-term changes in gene expression that may contribute to hyperexcitability following a sudden, profound loss of auditory input to one ear. We used fluorescence in situ hybridization to quantify mRNA levels for genes encoding AMPA ...
Source: Neuroscience - Category: Neuroscience Source Type: research
We describe a 77-year-old man with spontaneous concurrent spinal and cranial SDHs, in whom the spinal SDH was identified 30 days before the intracranial chronic SDH. Diagnosis: Magnetic resonance imaging showed a spinal SDH at L4/L5. There was no paralysis, and the patient was managed conservatively. About 30 days after the onset of back pain, he experienced tinnitus and visual hallucination. Brain computed tomography showed a chronic SDH and midline shift. Interventions: Burr-hole evacuation was performed, and the patient's condition improved. Outcomes: At 5 months of follow-up, there was no recurrence of the spi...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive neuromodulation treatment that involves the induction of electrical currents in a targeted region of the brain with the ability to impact various functional processes (Chervyakov  et al., 2015). rTMS has shown to provide clinical improvement among a variety of neurological and psychiatric disorders and has been FDA-approved for treatment resistant depression (TRD). rTMS continues to undergo trials for other treatment indications including post-traumatic stress disorder (PT SD), generalized anxiety disorder (GAD), bipolar depression, schizophren...
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
ConclusionCameron ulcer is a rare cause of iron deficiency anemia from chronic blood loss. It is fatal but easily treatable ulcer at hiatal hernia. It very rare in pediatrics age particularly under five children and high index of suspicion is lifesaving.
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 6 April 2018Source: Journal of Taibah University Medical SciencesAuthor(s): Sylves Patrick, Chan Hui-Tze, Wan Hitam Wan-Hazabbah, Embong Zunaina, Yaakub Azhany, Ahmad Tajudin Liza-SharminiAbstractManagement of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness...
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
ConclusionBased on literature studied, there is no therapeutic response of tinnitus to transcranial direct current stimulation.ResumoIntroduçãoDevido à subjetividade do diagnóstico do zumbido e a suas diversas etiologias, o estabelecimento de um tratamento eficaz é complexo. Neste contexto surge a transcranial direct current stimulation, uma opção não invasiva, acessível para grande parte dos pacientes, e que tem apresentado bons resultados no tratamento de outros sintomas como dor crônica.ObjetivoAvaliar a resposta terapêutica do zumbido ao transcr...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Publication date: Available online 6 April 2018Source: Journal of Taibah University Medical SciencesAuthor(s): Sylves Patrick, Chan Hui-Tze, Wan Hitam Wan-Hazabbah, Embong Zunaina, Yaakub Azhany, Ahmad Tajudin Liza-SharminiAbstractManagement of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness...
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
Progress in drug development has brought a host of novel agents for the treatment of neurological disorders ranging from multiple sclerosis to chronic pain. However, the treatment of most neurological disorders is still dependent on older medications. This includes medications, such as carbamazepine, with clinical activity across a broad number of disorders. Carbamazepine was first approved in 1963 for the treatment of epilepsy but has been used for treating types of schizophrenia, bipolar disorder, neuropathic pain, tinnitus, and trigeminal neuralgia. Although this agent is safe and effective for many patients, there is a...
Source: JAMA Neurology - Category: Neurology Source Type: research
CONCLUSION: A mean aggregate annoyance score that could reliably distinguish participants who self-report health effects (or noise complaints) from those who do not could be one of several factors considered by jurisdictions responsible for decisions regarding wind turbine developments. However, the threshold value for acceptable changes and/or levels in aggregate annoyance has not yet been established and could be the focus of future research efforts. PMID: 29981034 [PubMed - in process]
Source: Canadian Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Can J Public Health Source Type: research
Conclusion Based on literature studied, there is no therapeutic response of tinnitus to transcranial direct current stimulation.
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
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