Pharmacoepidemiologic and in Vitro Evaluation of Potential Drug‐Drug Interactions of Sulfonylureas with Fibrates and Statins

ConclusionsUse of fenofibrate or gemfibrozil together with glyburide was associated with elevated overall risks for serious hypoglycemia. CYP inhibition seems unlikely to explain this observation. We speculate that a pharmacodynamic effect of fibrates (e.g., activate peroxisome proliferator‐activator receptor alpha) may contribute to these apparent interactions.

Source: British Journal of Clinical Pharmacology - February 18, 2014 Category: Drugs & Pharmacology Authors: H Schelleman, X Han, C M Brensinger, S K Quinney, W B Bilker, D A Flockhart, L Li, S Hennessy Tags: Drug safety Source Type: research