Translocation t(8;14) in multiple myeloma defines patients with very poor prognosis – single centre experience

Analysis of cytogenetic abnormalities in multiple myeloma (MM) currently represents one of the key aspects for prognostic and therapeutic stratification of patients in routine clinical practice. Differentiation of hyperdiploid and nonhyperdiploid state with the most common translocation analysis in IgH gene disruption and assessing other amendments (1q21, del17p) allows individual selection of appropriate therapy. Translocation t(8;14) with rearrangement of MYC oncogene is among the less common cytogenetic changes in MM.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2015 Category: Hematology Authors: P. Tomas, V. Miroslava, M. Jiri, B. Jana, B. Jaroslav, J. Marie, S. Vlastimil Source Type: research