Endothelial Nitric Oxide Synthase-Derived Nitric Oxide Prevents Dihydrofolate Reductase Degradation via Promoting S-Nitrosylation.

CONCLUSIONS: We conclude that S-nitrosylation of DHFR at cysteine 7 by eNOS-derived NO is crucial for DHFR stability. We also conclude that NO-induced stabilization of DHFR prevents eNOS uncoupling via regeneration of tetrahydrobiopterin, an essential eNOS cofactor. PMID: 26381869 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26381869?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 17, 2015 Category: Cardiology Authors: Cai Z, Lu Q, Ding Y, Wang Q, Xiao L, Song P, Zou MH Tags: Arterioscler Thromb Vasc Biol Source Type: research

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