VEGFR1 Pseudogene Expression and Function in Colorectal Cancer Cells

This study identifies FLT1P1 antisense as a critical regulator of VEGFR1 and VEGF-A expression in colorectal cancer cells, and highlights its role in regulation of the pathogenesis of colorectal cancer.
Implications: The VEGFR1 pseudogene, FLT1P1, is a novel and functional regulator of VEGF signaling and its targeting could be an alternative strategy to modulate its cognate/target gene expression and downstream activity in cancer. Mol Cancer Res; 13(9); 1274–82. ©2015 AACR.

Source: Molecular Cancer Research - September 13, 2015 Category: Cancer & Oncology Authors: Ye, X., Fan, F., Bhattacharya, R., Bellister, S., Boulbes, D. R., Wang, R., Xia, L., Ivan, C., Zheng, X., Calin, G. A., Wang, J., Lu, X., Ellis, L. M. Tags: Cell Death and Survival Source Type: research